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spider toxin
Spider toxins are a family of proteins produced by spiders which function as neurotoxins. The mechanism of many spider toxins is through blockage of calcium channels.
A remotely related group of atracotoxins operate by opening sodium channels. Delta atracotoxin produces potentially fatal neurotoxic symptoms in primates by slowing the inactivation of voltage-gated sodium channels. The structure of atracotoxin comprises a core beta region containing a triple-stranded a thumb-like extension protruding from the beta region and a C-terminal helix. The beta region contains a cystine knot motif, a feature seen in other neurotoxic polypeptides〔 and other spider toxins, of the CSTX family.
Spider potassium channel inhibitory toxins is another group of spider toxins. A representative of this group is hanatoxin, a 35 amino acid peptide toxin which was isolated from Chilean rose tarantula (''Grammostola rosea'', syn. ''G. spatulata'') venom. It inhibits the drk1 voltage-gated potassium channel by altering the energetics of gating. See also Huwentoxin-1 .
==See also==
* Raventoxin
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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